CRYSTALOMICS: A PATHWAY FORWARD FOR PROTEIN CRYSTALLIZATION

Protein-based therapeutics, specifically monoclonal antibodies (mAbs), have become the focus of pharmaceutical R&D over the last decade. While these biologics offer many possibilities when it comes to treating a variety of diseases, they also present considerable challenges during development.

All of these factors combined make manufacturing and delivery of protein-based therapeutics very difficult. If these drugs could be produced at lower viscosities, then a lower volume could be used, making subcutaneous delivery possible; this would also significantly reduce the risk of aggregates. Now, a treatment that typically requires an hour in a clinic could potentially become a simple injection at home.

This informative white paper by Althea covers the challenges of crystallization of proteins for therapeutic use and how to preserve efficiency during crystallization.

Learn more about a pathway forward for protein crystallization in the white paper below! 

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Managing Your Cold Supply Chain to Ensure Your Vaccinations Get to Where They’re Needed Most

World Courier is transporting Zika diagnostic test kits to and from South America.

Companies trust us to transport and store time- and temperature-sensitive products, and the urgent and sensitive Zika diagnostic test kits are no exception! In the midst of concerns, especially for the well-being of athletes, World Courier’s capability and expertise are another reason to have peace of mind.

The Zika virus was a huge fear for the 2016 Olympic summer games in Rio de Janeiro, Brazil. In the white paper below, World Courrier explains the process and challenges of transporting Zika tests for the 2016 Olympic games to ensure the safety of the Olympic athletes and those attending.

Take a look at the full white paper below!

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Optimizing Temperature Control for Biopharmaceuticals

This article first appeared in BioPharm International, October 1, Caroline Hroncich

Today pharma companies are faced with an ever-changing market that includes increased regulatory challenges, globalization, and heightened competition (1). Biopharma companies are rapidly expanding into emerging markets where there are new opportunities for drug development. Conversely, logistics companies must keep up with the demand, ensuring all storage technology is equipped to retain the safety and efficacy of a drug by the time it reaches the end of its journey.

This article by World Courier delves into these relevant industry topics:

  • Common considerations for shipping biopharmaceuticals;
  • Temperature management in extreme climates;
  • Recent advancements; and
  • Looking ahead.

Learn more about optimizing temperature control for biopharmaceuticals in the article below!  

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Q&A eBook with Bossard: How Will Industry 4.0 Impact Your Supply Chain?

Previously many of these technologies were emerging on their own, but not considered collectively. With a recent push toward an integrated approach, the Internet of Things, the focused effort is much more clear. While efforts are being made to allow technologies to be more interchangeable and data non-exclusive, much of the progress thus far has been disjointed….

This Q&A eBook with Bossard, published by the Generis Group, highlights Industry 4.0, the Internet of Things, full inventory transparency, and more!

Bossard creates solutions that enable you to achieve higher productivity while helping you to surface your potential. Connect with Bossard at our American Supply Chain Summit taking place April 24-25th in Orlando, FL.

Read the full eBook below:

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Spectrum: S-40 Jet, Made in Mexico: First Aircraft to be Completely Manufactured in the Country

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How many parts does an airplane have?  According to Boeing, a goliath in the U.S. Aerospace industry, there are over 6 million pieces that make up its  747.  Completely believable when you consider everything from cockpit parts, nuts, and bolts to tray tables and seatbelt buckles!

luxelife-20140825171342416-0825_18011_001_01bMexico has been persistent in working to elevate its position in the supply and demand industry for aerospace parts for several years. ProAereo 2012-2020, put in place by the Mexican government, is a national strategic program designed specifically to put Mexico among the top 10 countries in the world in aerospace manufacturing and production. And further, to make Mexico the first aerospace service HUB in Latin America.

In support of ProAereo’s goal, the Mexican government has established educational facilities and research centers geared to specifically enhance their potential in aerospace: grooming a talented workforce and creating infrastructure to ensure sustained capabilities in the industry.

The strategy is continuing to pay off as San Diego-based U.S. aircraft developer, Spectrum Aeronautical, is set to build their S-40 business jet in Mexico.  Spectrum says Mexicali was chosen due to the area’s population of highly skilled workers, and for its proximity to the “huge aerospace industrial infrastructure of Southern California.” Spectrum chief finance officer David Tenney says, “Mexico is really keen to develop its aerospace industry and the S-40 will be the first aircraft to be completely manufactured in the country.”

$300 Million is the sum needed to fund the project in its entirety. The Mexican bank, Bancomext, is providing a portion of the funds necessary while the remainder will be funded through U.S. and Mexican equity investors, Tenny explained.  “This will fund the aircraft through development, certification and into service. We are very pleased with the terms and hope to have all the money in place by the end of June,” he added.

IVEMSA offers full shelter Mexico manufacturing services. Learn how IVEMSA can help lower manufacturing costs and maximize efficiency.

Focusing on Sustainable Supply Chain Outcomes

Every industry has its own unique supply chain issues and are in need of solutions that support the optimal balance of efficiency and productivity. Equipment failures, unexpected urgent requirements, and supply chain disruptions are frustrating, costly, and nigh impossible to solve on your own. Smaller or unpredictable shipping requirements can also present problems–as well as opportunities.

So, what’s the solution here? 

In this brochure, XPO Logistics describes solutions that are applicable to a wide scope of commodities in a wide range of industries.

Check out the brochure below for your supply chain solutions!

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Inbound Logistics Solutions that Increase Manufacturing Efficiency

Least-cost manufacturing is a business imperative, and the goal is lean inventories with no wasted space, time, transportation, or labor in the inbound logistics process.

In this article, XPO Logistics reveals proven processes and systems to:

  • Reduce inventory through improved collaboration with suppliers;
  • Maximize production space and output;
  • Automate replenishment; and
  • Postpone inventory ownership through a vendor managed inventory model.

Find more inbound logistics solutions here.

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Case Study: Create An Automated, Efficient Inbound Logistics Process

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A leading manufacturer of commercial jetliners and military aircraft completed the design for a revolutionary new aircraft, and the production team set an aggressive build schedule to meet demand. 

What the leading manufacturer needed was to create an automated, efficient inbound logistics process to enable an unprecedented manufacturing pace–completing an aircraft every three days!

XPO Logistics was able to help this big idea take off. Click here to read the full case study and find out how XPO made this opportunity happen.
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Managing A Cold Supply Chain

In the build up to the American Biomanufacturing Summit, we sat down with James Klingelhoefer, Regional Sales Director at World Courier to discuss strategies to best manage a cold supply chain. In the article below, James discusses the challenges and opportunities in managing a cold supply chain, explains the most important elements to manage and provides advice to biomanufacturers who may be struggling with their cold supply chain management.
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To hear more biomanufacturing insights, join the discussion on May 10 – 11, 2016 in San Diego, CA.

Using IoT To Become An Informed Manufacturer: The Why and How

The inter-connectivity of objects is generating unprecedented opportunities for innovation within industrial and consumer markets.  IoT (Internet of things) defines this new connectivity.  Sensors embedded within objects allow them to communicate with each other while continually gathering and transmitting large volumes of data about the current state of the object and its surroundings.

Whether it be the communication of  a heart sensor with a health monitor, the communication of a car engine with the display dashboard or the coordination of transportation fleets based on their current location, IoT is changing the way individuals, businesses and industries interact with the world around them.  From an industrial perspective, IoT can enable streamlined processes, labor cost reductions and increased productivity through connectivity and automation.

Manufacturers will be able to reap great rewards from these new technologies, as IoT may be applied across multiple segments throughout the manufacturing value chain.  Cognizant, a global leader in business and technology services, has created a fantastic whitepaper that explains how IoT enables informed manufacturing and how manufacturers can jump-start their IoT journey.

The Cognizant whitepaper (below) breaks down the 4 elements in informed manufacturing organizations; informed products, processes, people and infrastructure. It describes the promise of and potential uses of IoT within manufacturing and also explains the steps that manufacturers should take on their road to becoming an informed manufacturing organization.

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To hear more from Cognizant, join them at Booth #15 at the American Manufacturing Summit 2016 taking place next month in Chicago!